People
BOCHAO ZHANG
Personal Statement
I'm a PhD student in Biomedical Science. This is my forth year. I have a cat. I like spicy food.Research Statement
My research focus on identification of B cell and T cell receptor and analysis of clonal overlap in repertoires from different tissues / B cell type. My identification method is based on using some conserved parts in germline as anchors to pinpoint the relative position of sequence to corresponding germline. I'm also working on finding the clonal overlaps among different tissues / cell type and quantification of this pattern.Projects
[3] Identification of B cell and T cell receptors using conserved parts[2] Analysis of similarity of BCR / TCR germlines and quantifying the accuracy of identification at certain length and mutation frequency
[1] Clonal overlaps in repertoires from different tissues / B cell type.
Publications
[3] Goenka, R., Matthews, A. H., Zhang, B., O'Neill, P. J., Scholz, J. L., Migone, T.-S., Leonard, W. J., Stohl, W., Hershberg, U., and Cancro, M. P. (2014) Local BLyS production by T follicular cells mediates retention of high affinity B cells during affinity maturation. J Exp Med 211, 45-56.[2] Hershberg, U., Meng, W., Zhang, B., Haff, N., St Clair, E. W., Cohen, P. L., McNair, P. D., Li, L., Levesque, M. C., and Luning Prak, E. T. (2014) Persistence and selection of an expanded B cell clone in the setting of rituximab therapy for Sjogren's syndrome. Arthritis Research & Therapy 16, R51.
[1] Meng, W., Jayaraman, S., Bochao, Z., Schwartz, G. W., Daber, R., Hershberg, U., Garfall, A., Carlson, C. S., and Luning Prak, E. T. (2014) Trials and Tribulations with VH Replacement. Frontiers in Immunology 5.